Physical limitations and lack of necessary physical skills are one of the main causes of behavioral problems in children with Autism Spectrum Disorder (ASD) as a neurodevelopmental disorder with a significant prevalence. Motor exercises can affect a child's physical, perceptual, and behavioral problems. The aim of the present study was to determine the effectiveness of selected perceptual-motor exercises on the behavioral problems of second level autistic boys aged 8 to 12 years. In a semi-experimental study, 16 boys with autism and an age range of 8 to 12 years were studied in one of the autism centers in Tehran. perceptual-motor exercises were performed for 6 weeks and 2 sessions in week. The behavioral problems questionnaire of Johannes was filled out by parents. Multivariate data analysis of covariance showed that there was a significant difference between the intervention group and control group in the post-experimental frequency of self-harm behaviors, and stereotypes at the level (p < 0/001). There was also a significant difference between the intervention and control groups in post-test severity of self-harm behaviors and stereotypes (p < 0/05). The results showed that perceptual-motor exercises were effective in reducing the frequency and severity of ASD children's behaviors and self-harm behaviors. But these exercises did not significantly affect the aggressive behaviors of boys with ASD. Based on the findings of the present study, perceptual-motor exercises can be effective in reducing behavioral problems of autistic boys. It is recommended to be used as an appropriate intervention.